Neptunyl(VI) centred visible LMCT emission directly observable in the presence of uranyl(VI)

Room temperature detection of neptunyl(VI) LMCT emission in a coordination compound and in the presence of uranyl(VI) is reported for the first time. Differences in the excitation profiles of the complexes enable spectral editing so either exclusively neptunyl(VI) or uranyl(VI) emission is observed or a sum of the two

Angioleiomyoma of the small intestine – a rare cause of gastrointestinal bleeding

<p>Abstract</p> <p>Background</p> <p>Benign tumors are a rare cause of gastrointestinal hemorrhage of which angioleiomyomas constitute a very small minority. They have been reported in literature to present with volvulus, bleeding or intussusceptions.</p> <p>Case presentation</p> <p>An interesting case of a patient presenting with gastrointestinal bleeding from an underlying angioleiomyoma is discussed along with its management options.</p> <p>Conclusion</p> <p>Angioleiomyoma though rare can be managed successfully by surgical and/or minimally invasive endovascular procedures.</p

Discovery and integration of Web 2.0 content into geospatial information infrastructures: a use case in wild fire monitoring

Efficient environment monitoring has become a major concern for society to guarantee sustainable development. For instance, forest fire detection and analysis is important to provide early warning systems and identify impact. In this environmental context, availability of up-to-date information is very important for reducing damages caused. Environmental applications are deployed on top of GeospatialInformation Infrastructures (GIIs) to manage information pertaining to our environment. Suchinfrastructures are traditionally top-down infrastructures that do not consider user participation. This provokes a bottleneck in content publication and therefore a lack of content availability. On the contrary mainstream IT systems and in particular the emerging Web 2.0 Services allow active user participation that is becoming a massive source of dynamic geospatial resources. In this paper, we present a webservice, that implements a standard interface, offers a unique entry point for spatial data discovery, both in GII services and web 2.0 services. We introduce a prototype as proof of concept in a forest fire scenario, where we illustrate how to leverage scientific data and web 2.0 conten

Evolutionary conservation of TFIIH subunits: Implications for the use of zebrafish as a model to study TFIIH function and regulation

Transcriptional factor IIH (TFIIH) is involved in cell cycle regulation, nucleotide excision repair, and gene transcription. Mutations in three of its subunits, XPB, XPD, and TTDA, lead to human recessive genetic disorders such as trichothiodystrophy and xeroderma pigmentosum, the latter of which is sometimes associated with Cockayne's syndrome. In the present study, we investigate the sequence conservation of TFIIH subunits among several teleost fish species and compare their characteristics and putative regulation by transcription factors to those of human and zebrafish. We report the following findings: (i) comparisons among protein sequences revealed a high sequence identity for each TFIIH subunit analysed; (ii) among transcription factors identified as putative regulators, OCT1 and AP1 have the highest binding-site frequencies in the promoters of TFIIH genes, and (iii) TFIIH genes have alternatively spliced isoforms. Finally, we compared the protein primary structure in human and zebrafish of XPD and XPB – twoimportant ATP-dependent helicases that catalyse the unwinding of the DNA duplex at promoters during transcription – highlighting the conservation of domain regions such as the helicase domains. Our study suggests that zebrafish, a widely used model for many human diseases, could also act as an important model to study the function of TFIIH complex in repair and transcription regulation in humans.This research was partially supported by the European Regional Development Fund (ERDF) through the COMPETE-Operational Competitiveness Programme and national funds through FCT — Foundation for Science and Technology, under the project “PEst-C/MAR/LA0015/2011”